Shedding and Transmission of Novel Influenza Virus A/H1N1 Infection in Households—Germany, 2009
Identifieur interne : 002621 ( Main/Exploration ); précédent : 002620; suivant : 002622Shedding and Transmission of Novel Influenza Virus A/H1N1 Infection in Households—Germany, 2009
Auteurs : Thorsten Suess [Allemagne] ; Udo Buchholz ; Susann Dupke ; Roland Grunow ; Matthias an der Heiden ; Alla Heider ; Barbara Biere ; Brunhilde Schweiger ; Walter Haas ; Gérard KrauseSource :
- American Journal of Epidemiology [ 0002-9262 ] ; 2010.
Abstract
Essential epidemiologic and virologic parameters must be measured to provide evidence for policy/public health recommendations and mathematical modeling concerning novel influenza A/H1N1 virus (NIV) infections. Therefore, from April through August of 2009, the authors collected nasopharyngeal specimens and information on antiviral medication and symptoms from households with NIV infection on a daily basis in Germany. Specimens were analyzed quantitatively by using reverse transcriptase-polymerase chain reaction. In 36 households with 83 household contacts, 15 household contacts became laboratory-confirmed secondary cases of NIV. Among 47 contacts without antiviral prophylaxis, 12 became cases (secondary attack rate of 26%), and 1 (8%) of these was asymptomatic. The mean and median serial interval were 2.6 and 3 days, respectively (range: 1–3 days). On average, the authors detected viral RNA copies for 6.6 illness days (treated in time = 5.7 days, not treated in time = 7.1 days; P = 0.06), but they estimated that most patients cease to excrete viable virus by the fifth illness day. Shedding profiles were consistent with the number and severity of symptoms. Compared with other nasopharyngeal specimen types, nasal wash was the most sensitive. These results support the notion that epidemiologic and virologic characteristics of NIV are in many aspects similar to those of seasonal influenza.
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DOI: 10.1093/aje/kwq071
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must be measured to provide evidence for policy/public health recommendations and mathematical modeling concerning novel influenza A/H1N1 virus (NIV) infections. Therefore, from April through August of 2009, the authors collected nasopharyngeal specimens and information on antiviral medication and symptoms from households with NIV infection on a daily basis in Germany. Specimens were analyzed quantitatively by using reverse transcriptase-polymerase chain reaction. In 36 households with 83 household contacts, 15 household contacts became laboratory-confirmed secondary cases of NIV. Among 47 contacts without antiviral prophylaxis, 12 became cases (secondary attack rate of 26%), and 1 (8%) of these was asymptomatic. The mean and median serial interval were 2.6 and 3 days, respectively (range: 1–3 days). On average, the authors detected viral RNA copies for 6.6 illness days (treated in time = 5.7 days, not treated in time = 7.1 days; P = 0.06), but they estimated that most patients cease to excrete viable virus by the fifth illness day. Shedding profiles were consistent with the number and severity of symptoms. Compared with other nasopharyngeal specimen types, nasal wash was the most sensitive. These results support the notion that epidemiologic and virologic characteristics of NIV are in many aspects similar to those of seasonal influenza.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Biere, Barbara" sort="Biere, Barbara" uniqKey="Biere B" first="Barbara" last="Biere">Barbara Biere</name><name sortKey="Buchholz, Udo" sort="Buchholz, Udo" uniqKey="Buchholz U" first="Udo" last="Buchholz">Udo Buchholz</name><name sortKey="Dupke, Susann" sort="Dupke, Susann" uniqKey="Dupke S" first="Susann" last="Dupke">Susann Dupke</name><name sortKey="Grunow, Roland" sort="Grunow, Roland" uniqKey="Grunow R" first="Roland" last="Grunow">Roland Grunow</name><name sortKey="Haas, Walter" sort="Haas, Walter" uniqKey="Haas W" first="Walter" last="Haas">Walter Haas</name><name sortKey="Heider, Alla" sort="Heider, Alla" uniqKey="Heider A" first="Alla" last="Heider">Alla Heider</name><name sortKey="Krause, Gerard" sort="Krause, Gerard" uniqKey="Krause G" first="Gérard" last="Krause">Gérard Krause</name><name sortKey="Matthias An Der Heiden" sort="Matthias An Der Heiden" uniqKey="Matthias An Der Heiden" first="" last="Matthias An Der Heiden">Matthias an der Heiden</name><name sortKey="Schweiger, Brunhilde" sort="Schweiger, Brunhilde" uniqKey="Schweiger B" first="Brunhilde" last="Schweiger">Brunhilde Schweiger</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Suess, Thorsten" sort="Suess, Thorsten" uniqKey="Suess T" first="Thorsten" last="Suess">Thorsten Suess</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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